Manon E. W. Beekhuijzen: search on Z-Library

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1

Update of OECD DART guidelines with endocrine disruptor relevant endpoints: Practical considerations

Beekhuijzen, Manon, van Otterdijk, Francois, Wieland, Willemien, van Tuyl, Miranda, Rijcken, Robert Pels, Peter, Birgit, Emmen, Harry

Journal:

Reproductive Toxicology

Year:

2016

Language:

english

File:

PDF, 399 KB

english, 2016

2

Visualizing Compound Distribution during Zebrafish Embryo Development: The Effects of Lipophilicity and DMSO

de Koning, Coco, Beekhuijzen, Manon, Tobor-Kapłon, Marysia, de Vries-Buitenweg, Selinda, Schoutsen, Dick, Leeijen, Nico, van de Waart, Beppy, Emmen, Harry

Journal:

Birth Defects Research Part B: Developmental and Reproductive Toxicology

Year:

2015

Language:

english

File:

PDF, 3.58 MB

english, 2015

3

OECD DART guidelines update: Addition of endocrine disruptor relevant endpoints

Beekhuijzen, Manon

Journal:

Reproductive Toxicology

Year:

2016

Language:

english

File:

PDF, 45 KB

english, 2016

4

Guidance on the selection of cohorts for the extended one-generation reproduction toxicity study (OECD test guideline 443)

Moore, Nigel P., Beekhuijzen, Manon, Boogaard, Peter J., Foreman, Jennifer E., North, Colin M., Palermo, Christine, Schneider, Steffen, Strauss, Volker, van Ravenzwaay, Bennard, Poole, Alan

Journal:

Regulatory Toxicology and Pharmacology

Year:

2016

Language:

english

File:

PDF, 396 KB

english, 2016

5

The Urgency for Optimization and Harmonization of Thyroid Hormone Analyses and Their Interpretation in Developmental and Reproductive Toxicology Studies

Beekhuijzen, Manon, Schneider, Steffen, Barraclough, Narinder, Hallmark, Nina, Hoberman, Alan, Lordi, Sheri, Moxon, Mary, Perks, Deborah, Piersma, Aldert H., Makris, Susan L.

Journal:

Reproductive Toxicology

Year:

2018

Language:

english

File:

PDF, 341 KB

english, 2018

6

Comparison of in vitro and in vivo Developmental Toxicity and Pharmacokinetics of Phenytoin in the Rat

Manon E. W. Beekhuijzen, Aart Verhoef, Rob Klaassen, Cathy J. M. Rompelberg, Aldert H. Piersma

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2000

Language:

english

File:

PDF, 164 KB

english, 2000

7

To mate or not to mate: A retrospective analysis of two-generation studies for evaluation of criteria to trigger additional mating in the extended one-generation design

Manon Beekhuijzen, Amy Zmarowski, Harry Emmen, Wilbert Frieling

Journal:

Reproductive Toxicology

Year:

2009

Language:

english

File:

PDF, 143 KB

english, 2009

8

To mate or not to mate: A retrospective analysis of fourteen two-generation studies for evaluation of the added value of a second generation. An update

Manon Beekhuijzen, Birgit Peter, Amy Zmarowski, Harry Emmen

Journal:

Reproductive Toxicology

Year:

2010

Language:

english

File:

PDF, 44 KB

english, 2010

9

Implementing the extended one-generation reproductive toxicity study (EOGRTS). Important points to consider

Manon Beekhuijzen, Amy Zmarowski, Birgit Peter, Harry Emmen

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 91 KB

english, 2012

10

Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: Differences in baseline behavior and reactivity to positive control agents

Amy Zmarowski, Manon Beekhuijzen, Joost Lensen, Harry Emmen

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 43 KB

english, 2012

11

Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: Differences in baseline behavior and reactivity to positive control agents

Amy Zmarowski, Manon Beekhuijzen, Joost Lensen, Harry Emmen

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 904 KB

english, 2012

12

Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: Differences in baseline behavior and reactivity to positive control agents

Amy Zmarowski, Manon Beekhuijzen, Joost Lensen, Harry Emmen

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 65 KB

english, 2012

13

On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe

Emiel Rorije, André Muller, Manon E.W. Beekhuijzen, Ulla Hass, Barbara Heinrich-Hirsch, Martin Paparella, Erna Schenk, Beate Ulbrich, Betty C. Hakkert, Aldert H. Piersma

Journal:

Regulatory Toxicology and Pharmacology

Year:

2011

Language:

english

File:

PDF, 247 KB

english, 2011

14

Sensorimotor function in juvenile and adult Sprague–Dawley and Wistar Han rats

Amy Zmarowski, Manon Beekhuijzen, Marleen Teunissen, Harry Emmen

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 85 KB

english, 2012

15

Obituary

Beekhuijzen, Manon, de Raaf, Michiel Alexander, Zmarowski, Amy, van Otterdijk, Francois, Peter, Birgit, Emmen, Harry

Journal:

Year:

1947

Language:

english

File:

PDF, 196 KB

english, 1947

16

The underestimated value of OECD 421 and 422 repro screening studies: Putting it in the right perspective

Beekhuijzen, Manon, de Raaf, Michiel Alexander, Zmarowski, Amy, van Otterdijk, Francois, Peter, Birgit, Emmen, Harry

Journal:

Reproductive Toxicology

Year:

2014

Language:

english

File:

PDF, 1021 KB

english, 2014

17

Zebrafish embryotoxicity test (ZET): The importance of internal exposure analyses

Beekhuijzen, Manon, de Koning, Coco, de Vries-Buitenweg, Selinda, Tobor-Kaplon, Marysia, Schoutsen, Dick, Leeijen, Nico, van de Waart, Beppy, Emmen, Harry

Journal:

Reproductive Toxicology

Year:

2014

Language:

english

File:

PDF, 58 KB

english, 2014

18

Introduction: Adverse Outcome Pathways – Future for DART testing

Beekhuijzen, Manon

Journal:

Reproductive Toxicology

Year:

2014

Language:

english

File:

PDF, 48 KB

english, 2014

19

From cutting edge to guideline: A first step in harmonization of the zebrafish embryotoxicity test (ZET) by describing the most optimal test conditions and morphology scoring system

Beekhuijzen, Manon, de Koning, Coco, Flores-Guillén, Maria-Eugenia, de Vries-Buitenweg, Selinda, Tobor-Kaplon, Marysia, van de Waart, Beppy, Emmen, Harry

Journal:

Reproductive Toxicology

Year:

2015

Language:

english

File:

PDF, 2.08 MB

english, 2015

20

Introduction on Pulmonary Arterial Hypertension and its relation to fetal development

de Raaf, Michiel Alexander, Beekhuijzen, Manon, Bogaard, Harm Jan

Journal:

Reproductive Toxicology

Year:

2015

Language:

english

File:

PDF, 54 KB

english, 2015

21

Endothelin-1 receptor antagonists in fetal development and pulmonary arterial hypertension

de Raaf, Michiel Alexander, Beekhuijzen, Manon, Guignabert, Christophe, Vonk Noordegraaf, Anton, Bogaard, Harm Jan

Journal:

Reproductive Toxicology

Year:

2015

Language:

english

File:

PDF, 814 KB

english, 2015

22

Fetal programming in right ventricular adaptation to pressure overload

Bogaard, Harm Jan, de Raaf, Michiel Alexander, Beekhuijzen, Manon

Journal:

Reproductive Toxicology

Year:

2015

Language:

english

File:

PDF, 54 KB

english, 2015

23

11th ETS Special Issue of Reproductive Toxicology

Beekhuijzen, Manon

Journal:

Reproductive Toxicology

Year:

2015

Language:

english

File:

PDF, 110 KB

english, 2015

24

Implementing the extended one-generation reproductive toxicity study (EOGRTS): important points to consider

Beekhuijzen, Manon, Barentsen, Helma, Marsden, Edward, Zmarowski, Amy, Aujoulat, Michel, Picut, Catherine, Sloter, Eddie

Journal:

Critical Reviews in Toxicology

Year:

2016

Language:

english

File:

PDF, 1.87 MB

english, 2016

25

Evaluating the use of the second species in embryo-fetal or prenatal developmental studies

Beekhuijzen, Manon, Allais, Linda, Davis, Sarah, Leroy, Marilin, Sawhney Coder, Prägati, Van Dycke, Kirsten

Journal:

Reproductive Toxicology

Year:

2016

Language:

english

File:

PDF, 49 KB

english, 2016

26

Effects of Capillary Microsampling on Toxicological Endpoints in Juvenile Rats

Niu, Xiaoyu, Beekhuijzen, Manon, Schoonen, Willem, Emmen, Harry, Wenker, Mira

Journal:

Toxicological Sciences

Year:

2016

Language:

english

File:

PDF, 245 KB

english, 2016

27

The era of 3Rs implementation in Developmental and Reproductive Toxicity (DART) Testing: current overview and future perspectives

Beekhuijzen, Manon

Journal:

Reproductive Toxicology

Year:

2017

Language:

english

File:

PDF, 545 KB

english, 2017

28

Satellite rats are redundant in embryo-fetal development studies

Beekhuijzen, Manon, de Lange, Yaomi, Lambregts, Ankie, Peter, Birgit, Wenker, Mira, Emmen, Harry

Journal:

Reproductive Toxicology

Year:

2017

Language:

english

File:

PDF, 570 KB

english, 2017

29

Developmental and reproductive toxicity testing – The next generation

Beekhuijzen, Manon

Journal:

Reproductive Toxicology

Year:

2017

Language:

english

File:

PDF, 45 KB

english, 2017

30

Enhanced method of dermal exposure (semi-occlusive) in rats during post-coitum and lactation: Improved animal welfare and study outcome

Hartman-Van Dycke, Kirsten, van Otterdijk, Francois, Beerens, Chantal, van der Eerden, Harrie, Emmen, Harry, Beekhuijzen, Manon

Journal:

Reproductive Toxicology

Year:

2017

Language:

english

File:

PDF, 57 KB

english, 2017

31

Optimization of semi-occlusive dermal exposure method in pregnant and lactating rats

Van Dycke, Kirsten Hartman, van Otterdijk, Francois, Beerens, Chantal, van der Eerden, Harrie, Emmen, Harry, Beekhuijzen, Manon

Journal:

Toxicology Letters

Year:

2017

Language:

english

File:

PDF, 53 KB

english, 2017

32

Is omphalocele a non-specific malformation in New Zealand White rabbits?

Daston, George P., Beekhuijzen, Manon

Journal:

Reproductive Toxicology

Year:

2018

Language:

english

File:

PDF, 749 KB

english, 2018

33

Best Practices for Developmental Toxicity Assessment for Classification and Labeling

Daston, George, Piersma, Aldert, Attias, Leonello, Beekhuijzen, Manon, Chen, Connie, Foreman, Jennifer, Hallmark, Nina, Leconte, Isabelle

Journal:

Reproductive Toxicology

Year:

2018

Language:

english

File:

PDF, 508 KB

english, 2018

34

Are we ready for alternative testing?

Beekhuijzen, Manon, Kleinstreuer, Nicole

Journal:

Reproductive Toxicology

Year:

2018

Language:

english

File:

PDF, 87 KB

english, 2018

35

A multi-institutional study benchmarking the zebrafish developmental assay for prediction of embryotoxic plasma concentrations from rat embryo–fetal development studies

Cassar, Steven, Beekhuijzen, Manon, Beyer, Bruce, Chapin, Robert, Dorau, Martina, Hoberman, Alan, Krupp, Eckart, Leconte, Isabelle, Stedman, Don, Stethem, Christine, van den Oetelaar, Daphne, Tornesi,

Journal:

Reproductive Toxicology

Year:

2019

Language:

english

File:

PDF, 1.60 MB

english, 2019

36

A multi-institutional study benchmarking the zebrafish developmental assay for prediction of embryotoxic plasma concentrations from rat embryo–fetal development studies

Cassar, Steven, Beekhuijzen, Manon, Beyer, Bruce, Chapin, Robert, Dorau, Martina, Hoberman, Alan, Krupp, Eckart, Leconte, Isabelle, Stedman, Don, Stethem, Christine, van den Oetelaar, Daphne, Tornesi,

Journal:

Reproductive Toxicology

Year:

2019

File:

PDF, 1.60 MB

2019

37

A critical evaluation of thyroid hormone measurements in OECD test guideline studies: Is there any added value?

Beekhuijzen, Manon, Rijk, Jeroen C.W., Meijer, Marieke, de Raaf, Michiel Alexander, Pelgrom, Sylvia

Journal:

Reproductive Toxicology

Year:

2019

Language:

english

File:

PDF, 566 KB

english, 2019

38

Recent updates on regulatory guidances for developmental toxicity testing of chemicals - OECD 414

Beekhuijzen, Manon

Journal:

Reproductive Toxicology

Year:

2019

Language:

english

File:

PDF, 111 KB

english, 2019

39

Is there a rationale for direct dosing of chemicals to nursing pups in the EOGRTS (OECD 443)?

Arts, Josje, Beekhuijzen, Manon

Journal:

Regulatory Toxicology and Pharmacology

Year:

2020

File:

PDF, 165 KB

2020